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[Objective] To study the effect of FRUCTUS GARDENIAE extract on the level of uric acid in hyperuricemia mice and investigate the mechanism.[Method] After intragastric administration of FRUCTUS GARDENIAE extract at different doses,the level of uric acid and the activity of xanthine oxidase(XOD) in hyperuricemia mice induced by potassium oxonate were respectively observed.[Result] Different doses of FRUCTUS GARDENIAE extract could obviously reduce the level of serum uric acid and inhibit the activity of XOD in hyperuricemia mice.However,extract had no significant effect on the level of serum uric acid in normal mice.[Conclusion] FRUCTUS GARDENIAE extract could significantly reduce the level of serum uric acid in hyperuricemia mice,which is related to its inhibitory effect on XOD.
[Objective] To study the effect of FRUCTUS GARDENIAE extract on the level of uric acid in hyperuricemia mice and investigate the mechanism. [Method] After intragastric administration of FRUCTUS GARDENIAE extract at different doses, the level of uric acid and the activity of xanthine oxidase (XOD) in hyperuricemia mice induced by potassium oxonate were respectively observed. [Result] Different doses of FRUCTUS GARDENIAE extract could obviously reduce the level of serum uric acid and inhibit the activity of XOD in hyperuricemia mice. Host, extract had no significant effect on the level of serum uric acid in normal mice. [Conclusion] FRUCTUS GARDENIAE extract extract could significantly reduce the level of serum uric acid in hyperuricemia mice, which is related to its inhibitory effect on XOD.