,Effects of allisartan, a new AT1 receptor blocker, on blood pressure and end-organ damage in hypert

来源 :中国药理学报(英文版) | 被引量 : 0次 | 上传用户:z1348891
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Aim: To investigate the effects of allisartan, a new angiotensin Ⅱ type 1 (AT1) receptor antagonist, on blood pressure (BP) and end-organ damage (EOD) in hypertensive rats and dogs. Methods: First, a single dose of allisartan was given intragastricaUy to evaluate the BP reduction in spontaneously hyper-tensive rats (SHRs), two kidney-one clip (2K1C) renovascular hypertensive rats and dogs, and Beagle dogs with angiotensin Ⅱ-induced hypertension. Second, aUisartan was mixed in rat chow for long-term treatment. After 4 months of drug admin-istration, rats were instrumented to determine BP and baroreflex sensitivity (BRS). Observation of morphologic changes was used to estimate EOD. Third, the acute toxicity of allisartan was compared with that of losartan in mice. Results: BP was significantly decreased after intragastric administration of allisartan in SHRs, 2K1C rats, 2K1C dogs and with allisartan exhibited an improved BRS and organ protective effects. Mice who were administered allisartan experi-enced less acute toxicity than those treated with losartan.Conclusion: Auisartan is highly effective for BP reduction and organ protection with low toxicity.
其他文献
Aim: Hippocampal neuronal network and synaptic impairment underlie leing and memory deficit in Alzheimer’s disease (AD) patients and animal models. In this pap
Aim:To characterize the functional and pharmacological features of agonist-induced hump currents in human α4β2-nicotinic acetylcholine receptors (nAChR).Metho
6月24~25日,旧金山邦瀚斯拍卖行“亚洲艺术品拍卖”取得了近950万美元的成交额,超过拍卖前估价的两倍。拍卖行方面认为,从预展开始,来自亚洲的买家抢滩中国艺术品的情况就十