论文部分内容阅读
许多研究显示孕妇严重牙周炎可导致早产、低体重儿等不良妊娠结局,其具体机制仍不清楚。白细胞介素是由多种细胞分泌的在细胞间相互作用,在免疫调节、炎症过程中起重要作用的细胞因子。国内外许多研究均证实IL-8与早产、胎膜早破、感染、子痫前期等关系密切。通过分析妊娠晚期孕妇龈沟液、唾液及血清中IL-8表达,来探讨孕妇牙周炎局部与全身炎症因子表达之间的联系,分析牙周炎导致不良妊娠结局的可能的发生机制。
Many studies have shown that severe periodontal inflammation in pregnant women can lead to adverse pregnancy outcomes such as premature birth and low birth weight. The exact mechanism remains unclear. Interleukins are cytokines that are secreted by many kinds of cells and play an important role in cell-cell interactions and immune regulation and inflammation. Many studies at home and abroad have confirmed that IL-8 is closely related to premature labor, premature rupture of membranes, infection, preeclampsia and so on. By analyzing the expression of IL-8 in gingival crevicular fluid, saliva and serum of pregnant women in the third trimester of pregnancy, the relationship between local inflammation and the expression of systemic inflammatory cytokines in pregnant women was explored, and the possible mechanism of periodontitis leading to adverse pregnancy outcomes was analyzed.