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NF-kB最初是由Sen和Baltimore等于1986年在B淋巴细胞提取物中检测到的一种核蛋白,它能与免疫球蛋白K轻链基因的增强kB序列(5’-GGGACTTTCC-3’)特异结合,并能促进K链基因表达,故命名为核转录因子kB。进一步研究表明,NF-kB是一种重要的核转录因子,由一个复杂的体系组成,它不仅存在于B细胞中,而且也存在于T细胞、胸腺细胞、树突状细胞、巨噬细胞等多种细胞中。可与多种细胞因子、粘附分子等基因启动子或增强子kB位点特异结合,启动和调节这些基因的转录,在机体免疫应答、炎性反应和细胞生长、发育、调控等方面发挥重要作用。近年来,研究发现NF-kB在危重症的发生、发展过程中起着重要作用,成为危重症治疗的新靶点。
NF-kB was originally a nuclear protein detected by Sen and Baltimore et al. In B lymphocyte extracts in 1986 and is capable of binding to the enhanced kB sequence (5’-GGGACTTTCC-3 ’) of the immunoglobulin K light chain gene Specific binding, and can promote K chain gene expression, so named nuclear transcription factor kB. Further studies have shown that NF-kB is an important nuclear transcription factor, composed of a complex system, it exists not only in B cells, but also in T cells, thymocytes, dendritic cells, macrophages, etc. In a variety of cells. It can specifically bind with many kinds of cytokines, adhesion molecules and other gene promoters or enhancer kB sites, and start and regulate the transcription of these genes, which plays an important role in the body’s immune response, inflammatory reaction and cell growth, development and regulation effect. In recent years, the study found that NF-kB plays an important role in the occurrence and development of critically ill patients, becoming a new target for the treatment of critically ill patients.