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目的研究类风湿关节炎(RA)患者血清脂联素(AD)变化及其意义。方法 ELISA法测定62例RA患者和22例健康志愿者血清中AD水平,同时行实时荧光定量PCR(RT-PCR)检测外周血单个核细胞(PBMC)ADmRNA含量。结果 RA活动组患者血清中AD水平高于RA稳定组和健康对照组(P<0.05),且与DAS28、血沉(ESR)、类风湿因子(RF)呈正相关(P<0.01)。但各组PBMC均未检测到ADmRNA。结论 AD可能在慢性炎症过程中发挥作用,进一步研究AD的来源及参与的病理过程,可能为靶向性治疗RA提供新的思路。
Objective To study the changes of serum adiponectin (AD) in patients with rheumatoid arthritis (RA) and its significance. Methods The serum levels of AD in 62 cases of RA patients and 22 healthy volunteers were measured by ELISA. AD mRNA expression in peripheral blood mononuclear cells (PBMCs) was detected by real-time fluorescence quantitative PCR (RT-PCR). Results The level of serum AD in patients with active RA was significantly higher than that in patients with stable RA and healthy controls (P <0.05), and positively correlated with DAS28, ESR and rheumatoid factor (RF) (P <0.01). However, no AD mRNA was detected in PBMC of all groups. Conclusion AD may play a role in the process of chronic inflammation. To further study the origin of AD and the pathological process involved may provide new ideas for targeted therapy of RA.