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树突状细胞(dendritic cell,DC)是当前发现的功能最强的专职抗原提呈细胞(antigen-presenting cell,APC),其作为机体适应性T细胞免疫应答的始动者和调控者,已成为目前器官移植领域的研究热点。本文就树突状细胞的生物学特性、体外扩增培养、诱导移植免疫耐受的机制等方面的研究进展做一综述。
Dendritic cells (DCs) are currently the most potent specialized antigen-presenting cells (APCs) that have been the initiators and regulators of adaptive T cell immune responses in the body Become the research hotspot in organ transplant field at present. In this paper, the biological characteristics of dendritic cells, in vitro expansion of culture, induction of immune tolerance and other mechanisms of research are reviewed.