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Extracolonic invasion of the duodenum and/or pancreatic head rarely occurs in patients with right hemico lon cancer.However,when necessary,combined radical op eration is a challenge to the surgeon.We reported 7 patients with locally advanced right hemicolon cancer who underwent combined right hemicolectomy(RH)and pancreaticoduo denectomy(PD)due to direct involvement of the duodenum or pancreatic head.This study included four males and three females with a mean age of 66.9±5.9 years.Computed tomog raphy(CT)scans revealed right hemicolon cancer with duo denal invasion(5 patients)and pancreatic invasion(2).The mean operation time was 410±64 minutes and the estimated blood loss was 514±157 m L.After the operation,the mean postoperative hospital stay was 22.1±7.2 days.Five patients had postoperative complications.The mean follow-up time was 16.4±5.9 months.During this period,three patients died from tumor recurrence,one from postoperative complications one from pulmonary disease,and two survived until the last scheduled follow-up.Five patients survived more than one year.Combined RH and PD for locally advanced right hemi colon cancer can be performed safely,thus providing a long term survival rate in selected patients in a high-volume center.