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目的：探讨人乳头瘤病毒（ＨＰＶ）１６、１８型感染与人乳腺癌病因学的关系。方法：采用免疫组化法（ＳＰ）检测 ＨＰＶ １６、１８ Ｅ６蛋白在 １０例正常乳腺组织，４５例乳腺癌组织中的表达并对癌组中 １３例 ＨＰＶ １６、１８ Ｅ６蛋白阳性材料进行 ＨＰＶ １６、１８ ＤＮＡ原位杂交检测。结果：癌组中 ＨＰＶ １６、１８ Ｅ６阳性率为 ５３．３％（２４／４５），而正常乳腺组织中均为阴性表达。 ＨＰＶ １６、１８ ＤＮＡ阳性率为 ３８．５％（ ５／１３）。结论：高危型 ＨＰＶ １６、１８感染可能涉及乳腺癌的发生过程。
Objective: To investigate the relationship between human papillomavirus (HPV) type 16 and 18 infection and the etiology of human breast cancer. METHODS: Immunohistochemistry (SP) was used to detect the expression of HPV 16 and 18 E6 protein in 10 cases of normal breast tissue and 45 cases of breast cancer. 13 cases of HPV 16 and 18 E6 protein positive materials in cancer group were treated with HPV 16 18 DNA in situ hybridization detection. Results: The positive rate of HPV 16 and 18 E6 in cancer group was 53.3% (24/45), but negative in normal breast tissue. The positive rate of HPV 16 and 18 DNA was 38.5% (5/13). Conclusion: High-risk HPV 16 and 18 infections may involve the development of breast cancer.