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作者研究了88例胸腺后T细胞恶性肿瘤的皮肤病变。43例皮肤受累,其中原发性16例,继发性27例。有五种临床病理亚型:Ⅰ型,经典皮肤T细胞淋巴瘤(CTCL)或MF(6例),皮肤病变常为多发或弥漫性红斑或斑块。瘤细胞小到中等,有脑回状或扭曲的核,浸润真皮乳头,瘤细胞亲表皮性,但仅3例形成明显的Pautrier微脓肿。都表达CD4/CD3。其中有1例患者病史9年,死亡前3个月证实有免疫母细胞转化。Ⅱ型,大细胞型CTCL(7例),皮损呈孤立性肿块或散在红斑性结节。瘤细胞大,有圆形或锯齿形核,核仁明显,核分裂相多
The authors studied skin lesions in 88 cases of thymic T-cell malignancies. There were 43 cases of skin involvement, including 16 primary cases and 27 secondary cases. There are five clinical pathomorphology subtypes: type I, classical cutaneous T-cell lymphoma (CTCL) or MF (6 cases), skin lesions often with multiple or diffuse erythema or plaques. The tumor cells were of small to moderate size, with gyral or distorted nucleus, infiltrated dermal papilla, and tumor cells pro-epidermis, but only 3 cases formed obvious Pautrier micro-abscesses. Both express CD4/CD3. One patient had a medical history of 9 years and 3 months before death, it was confirmed that there was immunoblast transformation. Type II, large-cell CTCL (7 cases), lesions were solitary masses or scattered in erythematous nodules. Large tumor cells with round or zig-zag nucleus, prominent nucleoli and many mitoses