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急性心肌梗死的猝死,大多是由于其并发症,其中因心律失常而死亡者约占16％。为预防心律失常的发生,Sodi-Pallers于1962年发表了葡萄糖—胰岛素—钾(G-I-K)溶液静脉滴注疗法,但其疗效尚有争论。为了了解G-I-K溶液的疗效原理,本文作者不仅从G-I-K溶液对心律失常发生的影响方面,并且从其对血液动力学等的影响方面,在实验性心肌梗死的动物中作了观察。在戌巴比妥钠静脉麻醉下,结扎狗的冠状动脉左前降支,使产生急性心肌梗死,对其中15只狗同时静滴G-I-K溶液(G-I-K组),每10分钟观察狗的心电图、脉搏、心排血量、左室压力、心肌收缩力、左室心肌张力、冠状动静脉的血清电解质和儿茶酚胺的变化,至结扎后60分钟为止。然后与结扎前的数
Sudden death of acute myocardial infarction, mostly due to its complications, of which about arrhythmia and death accounted for about 16%. To prevent arrhythmia, Sodi-Pallers published an intravenous infusion of a glucose-insulin-potassium (G-I-K) solution in 1962, but its efficacy is still debated. In order to understand the efficacy of the G-I-K solution, the authors observed not only the effects of the G-I-K solution on arrhythmias, but also their effects on hemodynamics and others in experimental myocardial infarction animals. Under sodium pentobarbital anesthesia, the left anterior descending coronary artery was ligated to make acute myocardial infarction. Fifteen of them were given intravenous GIK (GIK group) at the same time. The electrocardiogram, pulse, Cardiac output, left ventricular pressure, myocardial contractility, left ventricular myocardial tension, coronary arterial venous serum electrolytes and catecholamine changes to 60 minutes after the ligation. Then with the number before ligation