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甲状腺肿瘤的良恶性鉴别有时相当困难。核仁组成区相关蛋白(Nucleolar—Organizer Regior Associated Protein,AgNOR)的定量研究对区别肿瘤的良恶性、分类、分型及分级均有一定价值。我们用这一方法对73例甲状腺标本作了定量观察,以探讨AgNOR变化在甲状腺肿瘤的诊断学意义。 1 材料和方法 1.1 材料 选用我院档案中甲状腺肿瘤标本,简要复习临床资料,重检全部HE切片,选出良性肿瘤43例,其中伴上皮增生的腺瘤27例,不伴上皮增生的滤泡性腺瘤5例,乳头状腺瘤6例,不典型腺瘤5例。恶性肿瘤25例,其中乳头状癌15例,滤泡性癌10例。另选出正常甲状腺5例。每例选取有代表性的蜡块1个,重新常规切片染色后镜检,核实诊断后重新编号,Ag-NOR胶银染色。
Diagnosis of benign and malignant thyroid tumors can sometimes be difficult. The quantitative study of Nucleolar-Organizer Regior Associated Protein (AgNOR) has certain value in distinguishing between benign and malignant tumors, classification, classification and classification. We used this method to quantitatively observe 73 cases of thyroid specimens in order to investigate the diagnostic significance of AgNOR changes in thyroid tumors. 1 Materials and methods 1.1 Materials selected in our hospital thyroid tumor specimens, a brief review of clinical data, re-examination of all HE slices, 43 cases of benign tumors were selected, including 27 cases of epithelial adenomas, epithelial hyperplasia without follicles There were 5 cases of adenoma, 6 cases of papillary adenoma and 5 cases of atypical adenoma. There were 25 cases of malignant tumors, including 15 cases of papillary carcinoma and 10 cases of follicular carcinoma. Another 5 cases of normal thyroid gland were selected. In each case, one representative wax block was selected and re-contoured and stained for microscopic examination. The diagnosis was re-numbered and stained with Ag-NOR gel silver.