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分离Wistar大鼠乳鼠的心室肌细胞,向培养基中分别加入人参三醇组皂甙300μg/ml,钙通道阻滞剂异博定37.5μg/ml或钙通道激动剂BAY K 8644 5μmol/L。用斑片钳的连细胞电压钳法,记录加药前后L、T、B三型钙通道的单通道活动。确证了人参三醇组皂甙的钙通道阻滞作用,并揭示其作用机理在于使钙通道的开放时间缩短与开放概率减少。
Wistar rat ventricular myocytes were isolated and ginsenoside 300 μg/ml, calcium channel blocker eosin 37.5 μg/ml or calcium channel agonist BAY K 8644 5 μmol/L were added to the culture medium. The single-channel activity of the L, T, and B type calcium channels before and after dosing was recorded using patch clamp forceps. The calcium channel blockade of ginsenoside triazine saponin was confirmed, and it was revealed that its mechanism of action was to shorten the opening time and open probability of calcium channels.