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目的:探讨祛瘀汤联合西药治疗对非小细胞肺癌高凝状态的影响。方法:将60例非小细胞肺癌高凝状态患者随机分为2组各30例,对照组对患者高凝状态予以西药常规对症支持治疗,治疗组在对照组基础上加用祛瘀汤,比较2组治疗前后相关高凝状态指标水平变化情况及肺血栓栓塞与深静脉血栓栓塞发生率。结果:2组治疗前各项高凝状态指标组间比较,差异均无统计学意义(P>0.05)。经治疗后,2组组内前后比较,差异有统计学意义(P<0.05)。治疗后,治疗组活化部分凝血活酶时间(APTT)高于对照组,纤维蛋白原(FIB)、D-二聚体(D-D)、血小板计数(BPC)低于对照组,2组比较,差异有统计学意义(P<0.05)。治疗组肺血栓栓塞与深静脉血栓栓塞发生率分别为5.1%、2.6%,总栓塞率为7.7%;对照组肺血栓栓塞与深静脉血栓栓塞发生率分别为10.5%、15.8%,总栓塞率为26.3%,2组肺血栓栓塞发生率、深静脉血栓栓塞发生率比较,差异均有统计学意义(P<0.05)。结论:祛瘀汤联合西药治疗非小细胞肺癌高凝状态患者可有效改善各项凝血指标,肺血栓栓塞与深静脉血栓栓塞等血栓并发症也随之降低,疗效满意。
Objective: To investigate the Qushi decoction combined with Western medicine on non-small cell lung cancer hypercoagulable state. Methods: Sixty non-small cell lung cancer patients with hypercoagulable state were randomly divided into two groups of 30 patients. The control group was treated with routine symptomatic treatment of Western medicine in patients with hypercoagulable state. The treatment group was treated with Quxuetang on the basis of the control group Two groups before and after treatment related hypercoagulable state level changes and the incidence of pulmonary thromboembolism and deep venous thromboembolism. Results: There was no significant difference between the two groups before the treatment of hypercoagulable state indicators (P> 0.05). After treatment, the two groups were compared before and after, the difference was statistically significant (P <0.05). After treatment, the activated partial thromboplastin time (APTT) in the treatment group was significantly higher than that in the control group. The levels of fibrinogen (FIB), D-dimer (DD) and platelet count (BPC) in the treatment group were lower than those in the control group There was statistical significance (P <0.05). The incidence of pulmonary thromboembolism and deep venous thromboembolism in the treatment group were 5.1% and 2.6%, respectively, and the total embolization rate was 7.7%. The incidences of pulmonary thromboembolism and deep venous thromboembolism in the control group were 10.5% and 15.8% Was 26.3%. The incidence of pulmonary thromboembolism and deep venous thromboembolism in the two groups were significantly different (P <0.05). Conclusion: Qu Yu Decoction combined with Western medicine in non-small cell lung cancer patients with hypercoagulable state can effectively improve the coagulation index, pulmonary thromboembolism and deep vein thrombosis and other thrombotic complications also decreased, the effect is satisfactory.