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正常脑组织中仅含少量前列腺素(PG),脑缺血时脑组织中PG的浓度会大量增高。卒中病人脑脊液中PG的升高即提示缺血损伤期间产生PG增多。本研究测定了脑缺血再灌注时脑前列腺素E_2(PGE_2),前列腺素F_(2α)(PGF_(2α)),6-酮-前列腺素F_(1α)( 6-酮-PG_(1α)),血栓素B_2(TXB_2)的变化。 选60只雌沙土鼠分成6个再灌注组,乙醚浅麻下用动脉夹钳夹双侧颈动脉,5分钟后松开动脉夹。分别于再灌注,0,1,2.5,15,60分钟时用断头术处死鼠,迅速取出大脑半球并冷冻于液氮中。模拟手术的对照鼠40只,仅暴露但不阻断颈动脉,
Normal brain tissue contains only a small amount of prostaglandin (PG), cerebral ischemia in the brain tissue concentrations of PG will be greatly increased. Increased PG in cerebrospinal fluid of stroke patients suggests increased PG during ischemia. This study determined the effects of PGE 2, PGF 2α, 6-keto-PGF 1α on cerebral ischemia-reperfusion in rats, ), Thromboxane B_2 (TXB_2) changes. Sixty male gerbils were divided into 6 reperfusion groups. Arterial clamps were used to clamp the bilateral carotid arteries under light ether anesthesia and the artery clips were released after 5 minutes. Rats were sacrificed at the time of reperfusion, 0, 1, 2.5, 15 and 60 minutes respectively, and the hemispheres were quickly removed and frozen in liquid nitrogen. Forty control mice, mock-operated, were exposed but did not block the carotid artery,