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在将HMG-Co还原酶转化为胆固醇前体-甲羟戊酸的胆固醇生物合成中,HMG-CoA还原酶是这一转化过程中的限速酶。HMG-CoA还原酶抑制剂是治疗高胆固醇血症的药物,它具有降低血浆中总胆固醇和低密度脂蛋白胆固醇水平的活性。近期
In cholesterol biosynthesis that converts HMG-Co reductase to cholesterol precursor-mevalonate, HMG-CoA reductase is the rate-limiting enzyme in this conversion. HMG-CoA reductase inhibitors are drugs for the treatment of hypercholesterolemia, which have the activity of lowering the level of total cholesterol and low density lipoprotein cholesterol in plasma. Recently