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目的研究并分析肺癌患者使用右美托咪定进行麻醉后对其围术期免疫功能的影响。方法收集肺癌手术患者共78例,根据随机化分组原则分为对照组(39例)和观察组(39例),对照组接受全身麻醉,观察组则联合使用右美托咪定,将2组患者手术前、手术结束时以及手术后24 h的T淋巴细胞亚群、自然杀伤细胞、免疫球蛋白水平进行观察和对比。结果 2组患者在手术结束时以及手术后24 h的所有观察指标与手术前相比明显降低(P均<0.05);观察组在手术结束时、手术后24 h的所有观察指标显著高于对照组(P均<0.05)。结论在肺癌手术患者的麻醉过程中,联合右美托咪定在短时间内对患者的免疫功能不会造成明显的影响,值得推广应用。
Objective To study and analyze the effect of dexmedetomidine on perioperative immune function in patients with lung cancer. Methods A total of 78 lung cancer patients were collected and divided into a control group (39 cases) and an observation group (39 cases) according to the principle of randomization. The control group received general anesthesia, and the observation group used dexmedetomidine together. The T lymphocyte subsets, natural killer cells, and immunoglobulin levels were observed and compared before surgery, at the end of the surgery, and 24 hours after surgery. Results All observations at the end of surgery and at 24 h after surgery were significantly lower in the 2 groups (P<0.05). All observations in the observation group at the end of surgery and 24 hours after the operation were significantly higher than those of the control. Group (P all <0.05). Conclusion In the process of anesthesia for patients with lung cancer surgery, combined with dexmedetomidine will not cause significant impact on the patient’s immune function in a short time, and it is worth popularizing and applying.