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本实验以内耳生物电及耳蜗浦片为指标,观察硫代硫酸钠对顺氨氯铂(CDDP)耳中毒预防。实验豚鼠分三组,各10只。对照组注射生理盐水,阳性对照注射CDDP2mg/kg;预防组注射硫代硫酸钠800mg/kg,同时给予CDDP2mg/kg;三组均每日一次腹腔给药,共6d。结果:①耳内生物电0～80dB不同程度短声引起的耳蜗微音器电位与听神经动作电位幅值,预防组动物均高于阳性对照组,但两者均低于对照组;②耳蜗铺片,阳性对照组大部分动物耳蜗各回的毛细胞严重性缺损,预防组耳蜗病变仅局限在底回。结果表明硫代硫酸钠能减轻CDDP的耳毒性,为CDDP致聋的防治提供了一条新的研究途径。
In this experiment, bioelectrical activity in the inner ear and the earplugs were used as indexes to observe the prevention of ototoxicity caused by sodium thiosulfate on cisplatin (CDDP). Experimental guinea pigs divided into three groups, each 10. The control group was injected with normal saline and the positive control was injected with CDDP 2 mg / kg. The prophylaxis group was given 800 mg / kg of sodium thiosulfate and given CDDP 2 mg / kg. The three groups were administered intraperitoneally once a day for 6 days. Results: (1) The amplitude of auditory nerve action potentials and cochlear microphones caused by short-sightedness of 0 ~ 80dB in the ear were higher in the prevention group than in the positive control group, but both were lower than that in the control group; In the positive control group, most of the cochlear hair cells in each animal were severely damaged in their hair cells. Prevention of cochlear lesions was only limited to the bottom. The results show that sodium thiosulfate can reduce the ototoxicity of CDDP, which provides a new research approach for the prevention and treatment of deafness caused by CDDP.