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先天性心脏病(congenital heart disease,CHD)是一种最常见的出生缺陷,为自然流产和死胎最常见的原因之一。最近研究提示,在心脏发育中,NKx2.5,SCN5A等基因的异常,不但会导致人类CHD的发生,而且可能会影响成年后心脏的正常功能。CHD患者远期并发的心脏疾患可能与这些基因的异常有关。
Congenital heart disease (CHD) is one of the most common birth defects and is one of the most common causes of spontaneous abortion and stillbirth. Recent studies suggest that in heart development, abnormalities of genes such as NKx2.5 and SCN5A will not only lead to the occurrence of CHD in humans, but also affect the normal function of heart in adult rats. Long-term complications of heart disease in patients with CHD may be related to the abnormalities of these genes.