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目的:应用血管内超声(intravascular ultrasound,IVUS)技术探讨血清高敏性C反应蛋白(hsCRP)与冠心病不稳定型心绞痛(UAP)的关系。方法:38例拟诊为冠心病患者行冠状动脉造影(coronary angiography,CAG)和IVUS检查,其中8例患者经CAG和IVUS检查未发现冠脉有明显病变为对照组;30例经IVUS检查发现冠脉有明显狭窄病变,为冠心病组,其中UAP 18例、稳定型心绞痛(SAP)12例。检测所有患者的hsCRP浓度。结果:38例患者均有不同程度的内膜增厚;8例对照组无动脉粥样硬化(AS)斑块;30例冠心病患者IVUS示有不同类型的AS斑块。UAP组患者血清hsCRP水平显著高于SAP组及对照组;不稳定斑块组hsCRP水平高于稳定斑块组。结论:UAP患者血清hsCRP水平明显增高,提示hsCRP水平升高与AS斑块不稳定有关。
Objective: To investigate the relationship between serum hs-CRP and UAP in patients with coronary heart disease (CHD) by intravascular ultrasound (IVUS). Methods: Thirty-eight patients diagnosed as CHD underwent coronary angiography (CAG) and IVUS examinations. Eight of the 8 patients who were diagnosed by coronary artery stenosis by CAG and IVUS were not found as control group. Thirty patients were detected by IVUS Coronary stenosis was obvious, coronary heart disease group, including 18 cases of UAP, stable angina (SAP) in 12 cases. All patients were tested for hsCRP concentration. RESULTS: Thirty-eight patients had varying degrees of intimal thickening; eight patients had no atherosclerosis (AS) plaque; and 30 patients with coronary artery disease showed different types of AS plaque. The level of hsCRP in UAP group was significantly higher than that in SAP group and control group. The level of hsCRP in unstable plaque group was higher than that in stable plaque group. Conclusion: The serum hsCRP levels in patients with UAP are significantly higher, suggesting that the elevated hsCRP levels are associated with the instability of AS plaques.