前列腺肿瘤的生长几乎完全依靠雄激素受体途径,因此对前列腺癌的治疗围绕阻断这条途径为中心来制定。但是这种治疗往往是肿瘤发展到雄激素非依赖阶段最终治疗失败,在这些病例雄激素受体几乎都发生了突变,更多迹象表明肿瘤仍然继续生长发展。这种机制就是雄激素受体突变后仍然保持着其活性功能。雄激素受体突变后促进肿瘤继续发展的分子机制及其治疗策略仍缺乏统一认识,现就此作一综述。 The growth of prostate tumors depends almost entirely on the androgen receptor pathway, so the treatment of prostate cancer revolves around blocking this pathway as the center. However, this treatment is often the ultimate failure of the tumor to develop in the androgen-independent phase, in which almost all androgen receptors have been mutated, and further evidence suggests that the tumor continues to grow and develop. This mechanism is that the androgen receptor mutations still maintain its active function. Androgen receptor mutation to promote the continued development of cancer molecular mechanisms and treatment strategies are still lack of common understanding, this is a review.