目的研究黄花棘豆的抗缺氧作用。方法实验分为常压密闭抗缺氧、减压密闭抗缺氧及亚硝酸中毒实验3部分,每部分60只小鼠,予各组小鼠连续ig 7 d,于末次灌胃1 h后分别记录小鼠的生存时间,并测定、分析各组小鼠心脏和大脑中的SOD、MDA、Bcl-2、Bax和GSH-Px。结果与空白对照组比较,黄花棘豆高剂量组小鼠的缺氧暴露时间明显延长,各项生化指标均有改善(P<0.05)。结论黄花棘豆醇提物能够提高小鼠缺氧耐受力,具有一定的抗缺氧作用。 Objective To study the anti-hypoxic effect of Oxytropis dahurica. Methods The experiment was divided into three parts: airtight anti-anoxia, airtight anti-hypoxia and nitrous acid poisoning experiments. Each part of 60 mice, each group of mice continuous ig 7 d, after the last gavage 1 h The survival time of mice was recorded and the SOD, MDA, Bcl-2, Bax and GSH-Px in the heart and brain of each group were measured and analyzed. Results Compared with the blank control group, the hypoxia exposure time of the high dose Oxytropis flavophilum group was significantly prolonged and all the biochemical parameters were improved (P <0.05). Conclusion Oxytropis cortex alcohol extract can improve hypoxia tolerance in mice, with some anti-hypoxia effect.