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本实验动态观察了异丙肾上腺素性心肌梗塞大鼠血浆前激肽释放酶(PKA)和抗凝血酶Ⅲ(AT-Ⅲ)的变化,并探讨了它们之间及其与心肌缺血、梗塞间的关系。结果发现,首次皮下注射异丙肾上腺素后4小时,PKA已显著降低(P<0.05),AT-Ⅲ也有降低趋势;24小时两者均显著降低(P<0.01),且两者间呈正相关(r=0.59,P<0.05);48小时AT-Ⅲ几乎恢复到正常水平,PKA则仍显著降低;24小时PKA与血清谷草转氨酶活性及心电图Ⅱ导联J/R比值均呈负相关(r=-0.60,-0.78;P<0.05,0.01)。提示内源性凝血系统的激活在异丙肾上腺素导致大鼠心肌梗塞过程中可能具有重要作用,心肌梗塞后血浆AT-Ⅲ的降低主要与内源性凝血系统的激活有关。
This experiment dynamically observed the changes of plasma kallikrein (PKA) and antithrombin Ⅲ (AT-Ⅲ) in rats with isoproterenol-induced myocardial infarction, and explored their relationship with myocardial ischemia, infarction Relationship between. The results showed that PKA decreased significantly (P <0.05) and AT-Ⅲ decreased 4 hours after the first subcutaneous injection of isoproterenol, both of which decreased significantly at 24 hours (P <0.01), and there was a positive correlation between them (r = 0.59, P <0.05) .At the end of 48 hours, AT-Ⅲ almost returned to the normal level, PKA was still significantly lower; 24 hours PKA had a negative correlation with serum aspartate aminotransferase activity and J / R ratio = -0.60, -0.78; P <0.05, 0.01). It is suggested that the activation of endogenous coagulation system may play an important role in isoproterenol-induced myocardial infarction in rats. The decrease of plasma AT-Ⅲ after myocardial infarction is mainly related to the activation of endogenous coagulation system.