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左旋18甲基炔诺酮0.15mg与炔雌醇0.03mg配伍的超低剂量口服避孕滴丸,1983年在北京9个医院进行临床试验。总共1.035名育龄妇女服药9,413周期。3例漏服受孕,1例于服药第13周期时妊娠,失败率为0.13%妇女年。按生命表法统计,一年末时与药物有关的停药率仅5.93%妇女。本研究还作了代谢变化的观察。与国内现有其它避孕药相比,本配方有甾体激素总量小、效高、周期控制良好、副反应低等优点。
L-18 norgestrel 0.15mg and ethinyl estradiol 0.03mg compatibility of ultra-low doses of oral contraceptive pills, in 1983 in Beijing’s nine hospitals for clinical trials. A total of 1.035 women of reproductive age took 9,413 cycles. 3 cases missed pregnancy, 1 case of pregnancy at the 13th cycle, the failure rate was 0.13% of women’s years. According to the life table method, drug-related withdrawal rates at the end of the year were only 5.93% for women. This study also made the observation of metabolic changes. Compared with other existing contraceptives in China, the formula has the advantages of small total amount of steroid hormones, high efficacy, good cycle control and low side effects.