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肺心病急性发作期患者所存在的高凝状态和纤溶机能低下能使原发病加剧，甚至可引起多系统脏3功能衰竭。蛇毒抗栓酶Ⅲ号具有良好的抗凝、溶栓及降低血液粘稠度作用，有利于纠正高凝状态和纤溶机能失衡本文对30例住院肺心病患者随机分成蛇毒组（15例）和对照组（15例）。两组患者均给予常现抗感染，祛痰，平喘，低流量吸氧，利尿及解控等治疗。蛇毒组每天加用蛇毒抗栓酶Ⅲ号1单位溶于10％葡萄糖250ml静滴共10无结果表明：蛇毒组部分缓解所需天数明显少于对照组（3．5±1．7天比5．1±22天，P＜0．01），组织型纤溶酶原激活物（tPA）和6－酮－前列环素（6－K－PGF_(1α)）含量明显高于对照组（P＜0．01，P＜0．01）。提示蛇毒抗栓酶可能通过提高tPA及6－K－PGF_(1α)含量纠正高凝状态和纤溶功能低下，使基础治疗更好地发挥作用。
Pulmonary heart disease patients with acute episodes of hypercoagulability and fibrinolytic conditions can aggravate the primary disease, and even can cause multiple system dysfunction. Snake venom antithrombin III has a good anticoagulant, thrombolysis and reduce blood viscosity, is conducive to correct hypercoagulable state and fibrinolytic imbalance in this paper, 30 cases of hospitalized patients with pulmonary heart disease were randomly divided into snake venom group (15 cases) and Control group (15 cases). Two groups of patients were often given anti-infective, expectorant, asthma, low-flow oxygen, diuretic and anti-control treatment. Snake venom group plus snake venom antithrombin III unit 1 dissolved in 10% glucose 250ml intravenous infusion of a total of 10 no results show that: snake venom group was significantly less than the required number of days the control group (3.5 ± 1.7 days than 5 (P <0.01). The levels of tPA and 6-K-PGF_ (1α) were significantly higher than those of the control group (P <0.01, P <0.01). Suggest snake venom antithrombin may improve the coagulation status and fibrinolytic function by improving the content of tPA and 6-K-PGF_ (1α), make the basic treatment play a better role.