论文部分内容阅读
目的 探讨一氧化氮 (NO)、一氧化氮合成酶 (NOS)和高密度脂蛋白胆固醇 (HDL -c)在脑梗死患者发病过程中的含量变化及其意义。方法 检测 5 3例脑梗死急性期患者和 40例健康对照组血清中的NO、NOS和HDL -c的含量 ,并进行显著性检验和相关性分析。结果 与对照组比较 ,脑梗死患者NO和NOS含量显著高于对照组 (P <0 0 1,P <0 0 5 ) ,其中皮层动脉梗死组高于腔隙性梗死组 (P <0 0 1,P <0 0 5 )。而脑梗死组HDL -c显著低于对照组 ,其中皮层动脉梗死组低于腔隙性梗死组 (P <0 0 1) ,NO与HDL -c呈现负相关关系 (r =- 0 5 5 6 ,P <0 0 1)。结论 脑梗死患者体内自由基反应及HDL -c合成失去平衡 ,观察NO、NOS及HDL -c值的变化具有重要意义。
Objective To investigate the changes and significance of nitric oxide (NO), nitric oxide synthase (NOS) and high density lipoprotein cholesterol (HDL-c) in the pathogenesis of cerebral infarction. Methods Serum levels of NO, NOS and HDL-c were detected in 53 acute cerebral infarction patients and 40 healthy controls, and the significance test and correlation analysis were performed. Results Compared with the control group, the levels of NO and NOS in patients with cerebral infarction were significantly higher than those in the control group (P <0.01, P <0.05). The levels of NO and NOS in cerebral infarction group were higher than those in lacunar infarction group (P <0.01) , P <0 0 5). However, HDL-c in cerebral infarction group was significantly lower than that in control group, in which cortical artery infarction group was lower than lacunar infarction group (P <0.01), NO was negatively correlated with HDL-c (r = - 0 556 , P <0 0 1). Conclusions The free radical reaction and HDL-c synthesis in patients with cerebral infarction are out of balance. It is of great significance to observe the changes of NO, NOS and HDL-c.