滋养细胞肿瘤的治疗已有重大突破,但对其生物学特性和奇特转移方式的认识尚有争议,本文就其研究概况作一综述。 1.葡萄胎是否为真性肿瘤 葡萄胎的发病率与恶变率均随年龄的增长而上升,尤其是45岁以上孕妇,发病率比45岁以下者高20～25倍,恶变率也随之升高。但葡萄胎究竟属肿瘤性,抑非肿瘤性仍有争议。通常认为葡萄胎系发生于胎盘的良性肿瘤,继而导致胎儿死亡。Berkowitz用免疫组织化学等方法,发现人绒癌细胞 There have been major breakthroughs in the treatment of trophoblastic tumors, but the understanding of their biological characteristics and peculiar modes of metastasis remains controversial. This article reviews the general situation of their research. 1. Whether the hydatidiform mole is true tumor The incidence of hydatidiform mole and malignant transformation rate increases with age, especially pregnant women over the age of 45, the incidence of 20 to 25 times higher than those under 45 years, the rate of malignancy also will rise high. However, whether the hydatidiform mole, non-neoplastic tumor is still controversial. Mola moles are generally thought to occur in benign tumors of the placenta, which in turn lead to fetal death. Berkowitz using immunohistochemistry and other methods, found that human choriocarcinoma cells