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细胞粘附在肿瘤侵袭转移过程中发挥重要作用。Ｅ－钙粘蛋白（Ｅｃａｄｈｅｒｉｎ，ＥＣＤ）是维护上皮细胞形态和结构完整性和极性的重要分子。ＥＣＤ功能的丧失可使肿瘤细胞增生、侵袭和转移的能力增加１２。对耐药肿瘤细胞系的研究已取得很大进展，但其与肿瘤侵袭转移的关系
Cell adhesion plays an important role in tumor invasion and metastasis. E-cadherin (ECD) is an important molecule that maintains the morphology and structural integrity and polarity of epithelial cells. Loss of ECD function can increase tumor cell proliferation, invasion, and metastasis12. The research on drug-resistant tumor cell lines has made great progress, but its relationship with tumor invasion and metastasis