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目的观察磷酸肌酸钠对重度窒息新生儿血清肌酸磷酸激酶同工酶(CK-MB)和心肌肌钙蛋白I(cTnI)的影响。方法入选重度窒息新生儿60例,按照入院顺序随机分为治疗组和对照组,每组30例患儿,均给予常规对症支持治疗,治疗组在常规对症支持治疗基础上加用磷酸肌酸钠,1 g/d,静脉滴注,6～7 d为一疗程。比较治疗前后两组患儿血清CK-MB和cTnI水平的变化。结果治疗前两组患儿血清CK-MB和cTnI水平均高于正常水平,但两组间差异无统计学意义[治疗组分别为(68.7±18.7)U/L、(2.73±0.22)μg/L;对照组分别为(68.8±19.3)U/L、(2.85±0.20)μg/L](P>0.05)。治疗3 d后,治疗组血清CK-MB和cTnI水平显著下降[(24.4±3.1)U/L、(0.36±0.03)μg/L](P<0.01),接近正常水平;而对照组则在7 d后恢复至正常水平[(27.8±2.5)U/L、(0.77±0.03)μg/L]。结论磷酸肌酸钠能够快速有效地降低重度窒息新生儿血清CK-MB和cTnI的水平。
Objective To observe the effects of sodium creatine phosphate on serum creatine phosphokinase (CK-MB) and cardiac troponin I (cTnI) in neonates with severe asphyxia. Methods Sixty newborn infants with severe asphyxia were randomly divided into treatment group and control group according to the order of admission. Thirty children in each group were given conventional symptomatic and supportive treatment. The treatment group was given conventional sodium phosphate creatine , 1 g / d, intravenous infusion, 6 ~ 7 d for a course of treatment. The changes of serum CK-MB and cTnI in two groups before and after treatment were compared. Results The serum levels of CK-MB and cTnI in the two groups before treatment were all higher than those in the normal group, but there was no significant difference between the two groups [(68.7 ± 18.7) U / L and (2.73 ± 0.22) μg / L, while the control group was (68.8 ± 19.3) U / L, (2.85 ± 0.20) μg / L, respectively] (P> 0.05). After 3 days of treatment, the levels of serum CK-MB and cTnI in treatment group were significantly lower than those in control group [(24.4 ± 3.1) U / L, (0.36 ± 0.03) μg / L] (P <0.01) After 7 days, the patients returned to their normal levels [(27.8 ± 2.5) U / L, (0.77 ± 0.03) μg / L]. Conclusion Sodium creatine phosphate can quickly and effectively reduce the levels of serum CK-MB and cTnI in neonates with severe asphyxia.