他汀类药物的抗肿瘤作用近年来备受关注。研究发现,他汀类药物能抑制肿瘤细胞增殖,诱导其分化或凋亡,而对正常细胞无明显毒副作用。体外实验证明,他汀类药物可抑制Ras、RhoGTPase和核纤层蛋白异戊二烯化,影响细胞周期进程和凋亡相关基因表达,抑制血管形成等。现综述他汀类药物抗肿瘤的国内外研究进展。 The anti-tumor effect of statins has drawn much attention in recent years. The study found that statins can inhibit tumor cell proliferation, induction of differentiation or apoptosis, but no obvious side effects on normal cells. In vitro experiments show that statins can inhibit Ras, RhoGTPase and lamin protein prenylation, affecting cell cycle progression and apoptosis-related gene expression, inhibition of blood vessel formation and so on. Now summarize statin anti-tumor research progress at home and abroad.