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目的分析妊高症对胎儿脐带血N末端B型钠尿肽原的影响。方法选取2010年3月至2015年3月我院收治的300例妊高症孕妇作为观察组,将观察组的孕妇按妊高症严重程度分为轻度妊高症组(n=183)和中重度妊高症组(n=117),再选取同期300例健康孕妇作为对照组,测定三组孕妇腹中胎儿脐带血N末端B型钠尿肽原(NT-proBNP)含量。结果观察组脐动脉血和脐静脉血浓度均显著高于对照组,两组比较,差异有统计学意义(P<0.05),观察组中,中重度妊高症组的脐动脉血和脐静脉血浓度均显著高于轻度妊高症组,两组比较,差异有统计学意义(P<0.05)。结论当孕妇患有妊高症时,会导致胎儿脐带血N末端B型钠尿肽原升高,损害胎儿心功能。
Objective To analyze the effect of pregnancy induced hypertension on N-terminal natriuretic peptide in fetal umbilical cord blood. Methods From March 2010 to March 2015, 300 pregnant women with PIH admitted to our hospital were selected as the observation group. Pregnant women in the observation group were divided into mild PIH group (n = 183) according to the severity of PIH. (N = 117). Three hundred healthy pregnant women in the same period were selected as the control group. The content of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in fetal cord blood was measured in the three groups. Results The umbilical arterial blood and umbilical blood concentrations in the observation group were significantly higher than those in the control group. There was significant difference between the two groups (P <0.05). In the observation group, umbilical arterial blood and umbilical vein Blood concentrations were significantly higher than those of mild pregnancy-induced hypertension group, the difference between the two groups was statistically significant (P <0.05). Conclusion When pregnant women with pregnancy-induced hypertension, fetal umbilical cord blood lead to N-terminal B-type natriuretic peptide increased, impair fetal heart function.