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[目的]探讨糖耐量正常青年血清硫化氢(H2S)水平与血脂及体脂分布的关系.[方法]检测47例糖耐量正常的健康体检青年男性血清 H2S水平,同时测量身高、体质量、腰围(WC)、血压、内脏脂肪面积(VFA)、全身脂肪(TBF)、躯干脂肪含量(TFM)及肌肉含量,检测血三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、餐后2h血糖(2hPG).根据VFA中位数(82.4 cm2)分为观察组(VFA≥82.4 cm2)和对照组(VFA<82.4 cm2),比较并分析两组上述指标的差异.[结果]观察组体质量指数(BMI)、WC、TBF、TFM、FPG及LDL-C明显高于对照组,H2S水平明显低于对照组(P 0.05);Pearson相关分析显示,血 H2S水平与BMI、WC、VFA、TBF、TFM及LDL-C呈明显负相关(P <0.05);多元线性回归分析显示,LDL-C和WC是H2S水平的影响因素(P <0.05).[结论]糖耐量正常的青年男性,H2S水平随着内脏脂肪的增加而下降,并出现FPG 和LDL-C的增高,提示下降的H2S水平与LDL-C的增高和内脏脂肪的增加密切有关.“,”[Objective]The purpose of the study was to investigate the relationship among plasma hydro-gen sulfide(H2S)level,blood lipid and body lipid distribution in healthy young men with normal glucose tol-erance.[Methods]A total of 47 healthy volunteers with normal glucose tolerance were recruited.The following data were all collected from the subjects:height,body mass,weight,waist circumference(WC),blood pres-sure,visceral fat area(VFA),total body fat(TBF),total body fat content(TFM),muscles content,triglyc-eride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FPG),2h postprandial blood glucose(2hPG)and H2S level.Ac-cording to the median VFA(82.4 cm2),subjects were divided into two groups:the observation group(VFA≥82.4 cm2)and the control group(VFA <82.4 cm2).The above indexes were compared and analyzed be-tween the two groups.[Results]The body mass index(BMI),WC,TBF,TFM,FPG and LDL-C in the ob-servation group were significantly higher than those in the control group(P <0.05),while the level of H2S in the observation group was significantly lower than that in the control group(P <0.05).The other indexes be-tween the two groups did not show significant difference.Pearson correlation analysis showed that H2S level were negatively correlated with BMI、WC、VFA、TBF、TFM and LDL-C(P <0.05).Multivariate linear re-gression analysis showed that LDL-C and WC were the influencing factors of H 2S level(P <0.05).[Conclu-sion]With the increase of visceral fat,H2S level drops and FPG and LDL-C increase in healthy young men with normal glucose tolerance.It indicates that the dropping of H2S level is closely correlated to the increase of LDL-C and visceral adipose.