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目的探讨妊娠期高血压疾病(HDIP)孕妇合并高尿酸血症的妊娠结局及血清尿酸监测的临床价值。方法选取妊娠36~42周HDIP孕妇90例作为研究组,按照血尿酸水平分为高尿酸血症组(n=69)和正常尿酸组(n=21),选择同期正常妊娠孕妇作为对照组(n=90)。比较三组孕妇的生化指标和妊娠不良结局及其影响不良妊娠结局的危险因素。结果三组孕妇血清总蛋白、谷丙(草)转氨酶、乳酸脱氢酶、肌酐、尿素氨、三酰甘油、总胆固醇、高(低)密度脂蛋白胆固醇比较,差异均有统计学意义(P<0.05);高尿酸血症组孕妇早产、胎儿窘迫和新生儿窒息等发生率高于正常尿酸组及对照组(P<0.05);logistic回归显示,血清尿酸>357μmol/L是妊娠期高血压疾病孕妇不良妊娠结局的高危因素(OR=1.258,P<0.05)。结论合并高尿酸血症的妊娠期高血压疾病孕妇常伴多种生化指标异常,是母婴不良妊娠结局的高危因素。
Objective To investigate the clinical value of pregnancy outcome and serum uric acid monitoring in pregnant women with hypertensive disorder complicating pregnancy induced hypertension (HDIP). Methods Ninety pregnant women with HDIP at 36-42 weeks of gestation were selected as the study group. According to the level of serum uric acid, they were divided into hyperuricemia group (n = 69) and normal uric acid group (n = 21) n = 90). The biochemical indexes and adverse pregnancy outcomes of the three groups of pregnant women were compared and their risk factors affecting the outcome of adverse pregnancy were compared. Results The differences of serum total protein, aprotinin, lactate dehydrogenase, creatinine, urea ammonia, triglyceride, total cholesterol, high and low density lipoprotein cholesterol among the three groups were statistically significant (P <0.05). The incidence of preterm birth, fetal distress and neonatal asphyxia in hyperuricemia group was higher than that in normal uric acid group and control group (P <0.05). Logistic regression showed that serum uric acid> 357μmol / L was the risk of gestational hypertension Risk factors for adverse pregnancy outcome in pregnant women with disease (OR = 1.258, P <0.05). Conclusions Pregnant women with hypertensive disorder complicating hyperuricemia often have multiple biochemical abnormalities and are the risk factors of adverse pregnancy outcome.