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1972年在阿拉斯加西南地区流行病学调查表明,HBsAg 阳性率为6.4%,尤其在2岁以下儿童与 HBsAg 阳性者接触的家庭成员中新 HBV 感染率很高。在阿拉斯加HBsAg 阳性的坏死性脉管炎每年发病率为15/10万;在阿拉斯加爱斯基摩男性中每年发生肝细胞癌(HCC)者为11.2/10万。通过对 HBsAg 阳性的 HCC 患者的研究表明,其血清甲胎蛋白(AFP)于肿瘤症状出现前2年即已升高,因此对 HBsAg 携带者每年检查2次 AFP 将早期发现 HCC。此外,1981年对1600人实行3次剂最乙型肝炎疫苗接种
Epidemiological investigation in southwestern Alaska in 1972 showed that the positive rate of HBsAg was 6.4%, especially among the family members who were exposed to HBsAg positive children under 2 years of age. The annual incidence of HBsAg-positive necrotizing vasculitis in Alaska is 15/10 million; in Hamster, Alaska, there are 11.2 / 100,000 cases of hepatocellular carcinoma (HCC) per year. A study of HBsAg-positive HCC patients showed that serum alpha-fetoprotein (AFP) levels were elevated two years prior to the appearance of the tumor, so HBCs were detected early twice a week in HBsAg carriers. In addition, three doses of the most hepatitis B vaccine were administered to 1,600 in 1981