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众所周知,对人淋巴细胞给予各种刺激时可以诱发针对培养株化细胞和新鲜肿瘤细胞的非特异性杀伤活性。也有人以NK 细胞、异常杀伤细胞、淋巴因子致活的杀伤细胞(LAK)等各种名称进行报告的。在这些细胞各有异同的同时,其与NK 细胞、特异的细胞损伤性T 细胞(CTL)之间的关系尚有争论。由原来无NK 细胞的胸腺细胞来诱导这种杀伤细胞的情况来看,不考虑NK 细胞的影响,而探讨其来源和诱导机制是有意义的。作者曾发表将人胸腺细胞以PHA 或IL_(-2)进行刺激,诱导对K_(562)的杀伤活性,在其活性诱导时,推测IL_(-2)是属于本质性的,使用的IL_(-2)混有外源凝集素、干扰素等,但未能予以肯定。这次应用重组体LI_(-2)(rIL_(-2)、重组体IFN_-r 对于诱导人胸腺细胞的杀伤活性,作了进一步的探讨。
It is well-known that various stimulations on human lymphocytes can induce nonspecific killing activity against cultured and fresh tumor cells. Others are reported under various names such as NK cells, abnormal killer cells and lymphokine-activated killer cells (LAKs). While these cells have similarities and differences, their relationship with NK cells and specific CTLs remains controversial. From the original NK cell-free thymus cells to induce such killer cells, regardless of the impact of NK cells, and explore its origin and induction mechanism is meaningful. The authors have previously reported that when human thymocytes are stimulated with PHA or IL - (- 2) to induce K_ (562) cytotoxicity, it is presumed that IL_ (- 2) -2) mixed with lectin, interferon, etc., but failed to be sure. The recombinant LI_ (-2) (rIL _ (- 2), recombinant IFN_-r on the induction of human thymocyte killing activity was further explored.