灵芝-8是从灵芝菌丝体中提取出的一种新的分子量为12420 Da的免疫调节性蛋白,在氨基酸序列及预想的二级结构上均与免疫球蛋白分子重链的可变区有一定的相似性。该蛋白在体外具有凝聚活性及促有丝分裂原作用,在体内主要表现为免疫抑制作用,如抑制系统性过敏反应和Arthus反应,以及对糖尿病和同种异体组织移植模型具有免疫抑制作用等。灵芝-8通过调节抗体的产生及对粘附分子的影响而发挥其免疫调节作用。 Ganoderma lucidum-8 is a new immunomodulatory protein with a molecular weight of 12420 Da extracted from mycelium of Ganoderma lucidum. It has both the amino acid sequence and the predicted secondary structure and the variable region of the heavy chain of immunoglobulin molecules. Certain similarities. The protein has cohesive activity and mitogen-inducing effect in vitro, and mainly exhibits immunosuppressive effects in vivo, such as inhibition of systemic anaphylaxis and Arthus reaction, and immunosuppressive effects on diabetes and allograft tissue transplantation models. Ganoderma lucidum-8 exerts its immunomodulatory effect by regulating the production of antibodies and its effect on adhesion molecules.