本文报道3例发生在经期的周期性血小板减少。3例在经期血小板最低值为5～20×100~9/L。血小板减少伴有紫癜、鼻衄和月经过多。5～14天后,血小板数恢复正常或上升至900×100~9/L。为明确这种病例血小板减少的机理,作者观察了血小板抗体、血小板清除率和单核细胞 Fcγ受体表达的变化。结果 3例在月经开始时均有明显的血小板减少,5～14天后恢复正常。2例在血小板数减少期间及血小板数恢复正常后,血小板相关抗糖蛋白Ⅰb 自 This article reports three cases occurred in the menstrual period of thrombocytopenia. The lowest value of platelet in 3 cases was 5 ~ 20 × 100 ~ 9 / L. Thrombocytopenia with purpura, epistaxis and menorrhagia. After 5 ~ 14 days, the number of platelets returned to normal or increased to 900 × 100 ~ 9 / L. To clarify the mechanism of thrombocytopenia in this case, the authors observed changes in platelet antibodies, platelet clearance, and monocyte Fcγ receptor expression. Results 3 cases had obvious thrombocytopenia at the beginning of menstruation and returned to normal after 5 ~ 14 days. 2 cases in the platelet number decreased and the number of platelets returned to normal after platelet-associated anti-glycoprotein Ib self