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目的对2011年7月-2016年8月期间桐庐县手足口病的流行病学特征以及病原体检测结果进行分析。方法应用荧光定量PCR法对辖区内290例手足口病临床诊断病例标本进行病原体检测,并结合基本临床资料进行分析。结果有211例肠道病毒(EV)阳性,阳性率72.8%;其中肠道病毒71型(EV71)阳性60例,柯萨奇病毒A组16型(Cox A16)阳性49例,分别占EV阳性标本的28.4%、23.2%;其他肠道病毒阳性102例,阳性率48.3%。结论桐庐县手足口病病原谱发生了较为明显的变化,优势病原体已转变为以其他肠道病毒为主,应在EV71和CoxA16监测基础上,还应加强对其他肠道病毒的分型监测。
Objective To analyze the epidemiological characteristics of hand-foot-mouth disease in Tonglu County from July 2011 to August 2016 and the results of pathogen detection. Methods The fluorescence quantitative PCR method was used to detect the pathogen of 290 cases of hand-foot-mouth disease in the area and combined with the basic clinical data. Results 211 cases of enterovirus (EV) positive, the positive rate of 72.8%; of which 60 cases of enterovirus 71 (EV71) positive, Cox A16 16 cases (Cox A16) positive 49 cases, respectively, EV positive The samples were 28.4% and 23.2% respectively. Other enterovirus positive cases were 102 cases, the positive rate was 48.3%. Conclusion The pathogen spectrum of hand, foot and mouth disease in Tonglu County changed obviously. The predominant pathogens had changed to other enterovirus. Based on the monitoring of EV71 and CoxA16, the typing of other enteroviruses should be strengthened.