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目的探讨控制性超促排卵对整个孕期母体心脏结构和功能的影响。方法 2014年1月~2014年12月共150名孕妇,其中人工助孕组共100例(鲜胚组和冻融组各50例),自然妊娠孕妇(正常组)50例,收集早孕与晚孕期心脏结构与功能相关数据。结果各组内比较,孕晚期孕妇舒张压较早孕稍降低、脉压差增大(P>0.05),但差异无统计学意义。右房内径、右室内径增宽,差异有统计学意义(P<0.05)。孕晚期心率较于孕早期三组均增加,但差异无统计学意义(P>0.05)。研究提示,三组间各项测量指标均无统计学差异(P>0.05)。结论体外受精-胚胎移植控制性超促排卵,短时间内超生理状态的甾体激素水平,以及冻融胚胎移植对于母体孕晚期的心脏结构及功能,并未造成不良影响。
Objective To investigate the effect of controlled ovarian hyperstimulation on the structure and function of maternal heart during the whole pregnancy. Methods A total of 150 pregnant women from January 2014 to December 2014 were enrolled. Among them, there were 100 cases of artificial pregnancy (50 cases in fresh embryo group and 50 cases in frozen-thawed group) and 50 cases in pregnant women (normal group) Data on cardiac structure and function during pregnancy. Results Compared with each group, the diastolic blood pressure of pregnant women in the second trimester was slightly lower than that of the first trimester, and the pulse pressure difference increased (P> 0.05), but the difference was not statistically significant. Right atrial diameter, right ventricular diameter widened, the difference was statistically significant (P <0.05). Compared with the third trimester, the third trimester heart rate increased in the second trimester, but the difference was not statistically significant (P> 0.05). The study suggests that there is no significant difference between the three groups (P> 0.05). Conclusions Controlled hyperstimulation in vitro fertilization and embryo transfer, hyperphysiological status of steroid hormone in a short period of time, and frozen-thawed embryo transfer have no adverse effect on the cardiac structure and function of maternal third trimester.