应用免疫组织化学的方法,研究103例结、直肠癌的c-neu、c-myc和P53癌基因蛋白的共同表达。103例中c-neu强阳性为42.7％,c-myc为39.8％,P53为13.5％。前两者之间的阳性率无显著差别,表明这两个癌基因在结、直肠癌的发生发展中具有相同的重要性。在103例中,14例的P53是与c-neu或c-myc共同表达的,无一例P53单独表达阳性。P53与c-neu,P53与c-myc的阳性率均有显著的统计学上差别(P<0.01)。 The co-expression of c-neu, c-myc, and P53 oncoproteins in 103 cases of colorectal cancer was studied by immunohistochemistry. In 103 cases, the strong positive for c-neu was 42.7%, c-myc was 39.8%, and P53 was 13.5%. There was no significant difference in the positive rates between the first two groups, indicating that these two oncogenes have the same importance in the occurrence and development of colorectal cancer. In 103 cases, 14 cases of P53 were co-expressed with c-neu or c-myc, and none of the cases were positive for P53 alone. The positive rates of P53 and c-neu, P53 and c-myc were significantly different (P<0.01).