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目的探讨趋化因子CXCL11和CXCL16在慢性乙型肝炎(CHB)患者外周血中的表达水平及其临床意义。方法用ELISA方法定量检测CHB患者外周血中CXCL11和CXCL16含量。以全自动生化分析仪检测CHB患者血清中ALT含量。结果CHB患者血清中CXCL11浓度为(247.73±76.58)ng/L,CXCL16的浓度为(7.42±0.64)μg/L,均高于正常对照组(P<0.05),其中CXCL11与ALT呈正相关(r值为0.702,P<0.05),而CXCL16与ALT之间无明显相关性(r值为-0.538,P>0.05)。结论CXCL11和CXCL16在CHB患者中明显升高,参与了机体对HBV的免疫反应过程,介导肝脏炎细胞浸润,参与了乙型肝炎慢性化病程。CXC16水平与血清ALT浓度无明显相关性。
Objective To investigate the expression of chemokine CXCL11 and CXCL16 in peripheral blood of patients with chronic hepatitis B (CHB) and its clinical significance. Methods The levels of CXCL11 and CXCL16 in peripheral blood of patients with CHB were measured by ELISA. The serum ALT level in patients with CHB was detected by automatic biochemical analyzer. Results The serum level of CXCL11 in CHB patients was (247.73 ± 76.58) ng / L and that of CXCL16 was (7.42 ± 0.64) μg / L, both of which were significantly higher than those of normal controls (P <0.05) Value of 0.702, P <0.05), while there was no significant correlation between CXCL16 and ALT (r value -0.538, P> 0.05). Conclusion CXCL11 and CXCL16 are significantly elevated in patients with CHB and are involved in the process of immune response to HBV, mediating the infiltration of hepatic inflammatory cells and participating in the chronic disease course of hepatitis B. CXC16 levels and serum ALT concentration no significant correlation.