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目的了解小汗腺汗孔癌的临床特征及组织病理特点。方法对第四军医大学西京皮肤医院2007年4月-2015年8月经组织病理学检查确诊的5例小汗腺汗孔癌患者的临床及组织病理特点进行回顾性分析。结果 5例小汗腺汗孔癌患者中,男3例,女2例,平均年龄66.8岁,中位年龄69岁,平均病程1.5年。皮损部位:鼻部1例,颞部1例,下肢3例。临床表现多为结节及斑块,多数皮损伴有不同程度瘙痒、疼痛、糜烂及破溃。皮损组织病理可见排列紧密的团块状嗜伊红鳞状样细胞或基底样细胞,分布不典型,团块中央可见导管分化结构,细胞异型性明显。结论该病临床表现无明显特异性,确诊需要依靠组织病理检查。治疗上应早期予以手术切除皮损。若无转移病灶则预后较好。
Objective To understand the clinical features and histopathological features of sweat gland carcinoma. Methods The clinical and histopathological features of 5 patients with eczema and sweat pores diagnosed by histopathology from April 2007 to August 2015 at Xijing Skin Hospital of Fourth Military Medical University were analyzed retrospectively. Results Among 5 patients with eczema and sweat pores, there were 3 males and 2 females with an average age of 66.8 years and a median age of 69 years with an average duration of 1.5 years. Lesions site: nose in 1 case, 1 case of temporal, 3 cases of lower limbs. Mostly clinical manifestations of nodules and plaques, most lesions accompanied by varying degrees of itching, pain, erosion and ulceration. Histopathological lesions showed closely arranged mass-like eosinophilic squamous cells or basal-like cells, the distribution is not typical, the central duct visible clumps differentiation structure, cell atypia obvious. Conclusion The clinical manifestations of the disease no obvious specificity, diagnosis need to rely on histopathological examination. Treatment should be early surgery to remove the skin lesions. Without metastasis, the prognosis is better.