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目的:探讨果糖二磷酸钠联合高压氧(HBO)治疗急性一氧化碳(CO)中毒心肌损伤患儿的临床疗效。方法:选取2012年12月至2019年12月期间济宁医学院附属医院儿科收治的急性CO中毒患儿96例，采用随机数字表法分为对照组和观察组，每组48例。对照组患儿进行HBO及常规对症支持治疗，观察组患儿在对照组的治疗基础上增加果糖二磷酸钠治疗。观察2组患儿的临床疗效、格拉斯哥昏迷评分(GCS)、血清肌酸激酶同工酶-MB(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)、脑尿钠肽(BNP)、肌红蛋白(MYO)、肌酸激酶(CK)及α-羟丁酸脱氢酶(α-HBDH)水平。结果:治疗后2组患儿的GCS评分和血清CK-MB、cTnⅠ、BNP、MYO、CK及α-HBDH水平较治疗前均明显改善，差异均有统计学意义(n P<0.05或n P<0.01)。观察组患儿临床治疗总有效率(97.92%)显著高于对照组(91.67%)，治疗后GCS评分明显高于对照组，血清CK-MB、cTnⅠ、BNP、MYO、CK及α-HBDH表达水平显著低于对照组，心电图改善总有效率(93.75%)显著高于对照组(85.42%)，差异均有统计学意义(n P<0.05或n P<0.01)。n 结论:HBO联合果糖二磷酸钠有利于促进急性CO中毒合并心肌损伤患儿清醒，修复损伤的心肌细胞，提高临床疗效。“,”Objective:To investigate the clinical effect of hyperbaric oxygen (HBO) combined with fructose diphosphate sodium on child patients with myocardial injury induced by acute carbon monoxide (CO) poisoning.Methods:A total of 96 cases of acute CO poisoning child patients admitted to the Department of Pediatrics of the Affiliated Hospital of Jining Medical University from December 2012 to December 2019 were selected and randomly divided into control group and observation group according to the random number table method, with 48 cases in each group. The control group was given conventional symptomatic and supportive treatment combined with HBO, while the observation group was given fructose diphosphate sodium on the basis of the treatments in the control group. The clinical effect, the Glasgow coma scale (GCS) score, the levels of serum creatine kinase-MB (CK-MB), cardiac troponin I (cTnⅠ), brain natriuretic peptide (BNP), myoglobin (MYO), creatine kinase (CK), and α-hydroxybutyrate dehydrogenase (α-HBDH) of the two groups were observed.Results:After treatment, the GCS scores and the levels of serum CK-MB, cTnⅠ, MYO, BNP, CK, and α-HBDH of the two groups were significantly improved compared with those before treatment, all with statistically significant differences ( n P<0.05 orn P<0.01). The total effective rate of the observation group (97.92%) was significantly higher than that of the control group (91.67%), with statistically significant difference (n P<0.05). After treatment, the GCS score of the observation group was significantly higher than that of the control group; the serum expression levels of CK-MB, cTnⅠ, MYO, BNP, CK, and α-HBDH in the observation group were significantly lower than those in the control group; the total effective rate of electrocardiogram improvement in the observation group (93.75%) was significantly higher than that in the control group (85.42%), all the above differences were statistically significant (n P<0.05 orn P<0.01).n Conclusion:HBO combined with fructose diphosphate sodium can enhance the clinical curative effect on child patients with acute CO poisoning by promoting their regain of consciousness and improving the myocardial injury.