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目的观察阿魏酸钠治疗慢性肾衰竭的临床疗效。方法 54例慢性肾衰竭患者随机分为对照组和阿魏酸钠组,对照组给予常规治疗,阿魏酸钠组在常规治疗的基础上加用阿魏酸钠,两组均持续治疗4周,观察治疗前后总胆固醇(TC)、甘油三酯(TG)、24h尿微量白蛋白(UAER)、血肌酐(SCr)、血尿素氮(BUN)、血红蛋白(Hb)浓度的变化。结果治疗后,阿魏酸钠组中TC、TG、UAER、SCr、BUN较治疗前明显降低,Hb浓度明显升高,差异均有统计学意义(P<0.05);对照组中有14例显效,4例有效,9例无效,总有效率为66.7%;阿魏酸钠组中23例显效,2例有效,2例无效,总有效率达92.6%,明显高于对照组,差异有统计学意义(χ2=5.734,P<0.05)。结论阿魏酸钠可有效减少尿蛋白,调整血脂水平,保护肾功能。
Objective To observe the clinical efficacy of sodium ferulate in the treatment of chronic renal failure. Methods Fifty-four patients with chronic renal failure were randomly divided into control group and sodium ferulate group. The control group was given routine treatment. The sodium ferulate group was treated with sodium ferulate on the basis of routine treatment. Both groups were treated for 4 weeks The levels of total cholesterol (TC), triglyceride (TG), 24h urinary albumin (UAER), serum creatinine (SCr), blood urea nitrogen (BUN) and hemoglobin (Hb) were measured before and after treatment. Results After treatment, the levels of TC, TG, UAER, SCr and BUN in the sodium ferulate group were significantly lower than those before treatment, and the Hb concentration was significantly increased (P <0.05); in the control group, 14 cases were markedly effective , 4 cases were effective, 9 cases were ineffective, the total effective rate was 66.7%; 23 cases in sodium ferulate group were effective, 2 cases were effective, 2 cases were ineffective, the total effective rate was 92.6%, significantly higher than the control group, the difference was statistically Significance (χ2 = 5.734, P <0.05). Conclusion Sodium ferulate can effectively reduce urinary protein, regulate blood lipid level and protect renal function.