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用国产胺苯吖定(AMSA)治疗急性白血病(AL)27例,剂量为70~90mg/m~2·d,连用5~7天,完全缓解(CR)率51.9%;其中急性淋巴细胞白血病(ALL)的 CR 率54%,急性非淋巴细胞白血病(ANLL)的 CR 率50%。初治病例疗效好于复治病例。主要毒性是骨髓抑制,尤为中性粒细胞的抑制。
27 cases of acute leukemia (AL) were treated with AMSA in the dose of 70-90mg / m ~ 2 · d for 5 ~ 7 days, with complete remission (CR) rate of 51.9%. Acute lymphoblastic leukemia (ALL) CR rate of 54%, acute non-lymphocytic leukemia (ANLL) CR rate of 50%. The initial treatment effect is better than re-treatment cases. The main toxicity is myelosuppression, especially neutrophil inhibition.