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检测了健康成人、某些胃肠病患者和其它疾病患者血清胃蛋白酶原亚类Ⅰ、Ⅱ(SPg Ⅰ、SPgⅡ)含量。结果表明,肠型胃癌SPgⅠ和SPgⅠ/SPgⅡ比值降低,胃型则否。萎缩性胃炎患者胃底腺粘膜萎缩愈重,SPgⅠ降低愈甚。消化性溃疡患者SPg Ⅰ、SPgⅡ含量升高,其中活动期十二指肠溃疡SPg Ⅰ升高尤为明显。此外,胃切除术后、肝硬化患者SPg Ⅰ、SPg Ⅱ降低,慢性肾功能衰竭则升高。SPgⅠ和SPgⅠ/SPgⅡ比值可作为肠型胃癌初步筛选、萎缩性胃炎严重程度判断和随访以及十二指肠溃疡病因和流行病学研究的一项新的血清学指标。
The levels of serum pepsinogen I, II (SPg I, SPg II) in healthy adults, certain gastrointestinal patients, and other diseases were measured. The results showed that the ratio of SPgI and SPgI/SPgII in intestinal type gastric cancer was lower, and the gastric type was not. The atrophic gastric mucosa in patients with atrophic gastritis is heavier, and the SPgI decreases even more. The contents of SPg I and SPg II in patients with peptic ulcer were increased, and the SPg I elevation in active duodenal ulcer was especially obvious. In addition, after gastrectomy, SPg I and SPg II decreased in patients with cirrhosis, and chronic renal failure increased. The ratio of SPgI and SPgI/SPgII can be used as a new serological marker for preliminary screening of intestinal type gastric cancer, judgment of atrophic gastritis severity and follow-up, and etiology and epidemiological study of duodenal ulcer.