目的观察长春地辛治疗难治性免疫性血小板减少性紫癜(ITP)的治疗效果和安全性。方法对8例难治性ITP的患者进行每周1次持续静脉滴注长春地辛治疗,随访记录治疗后患者临床出血症状及血小板计数,并观察有无不良反应发生。结果治疗后血小板升至100×109/L、无出血症状3例,治疗后血小板升至30×109/L或至少比基础血小板计数增加2倍、无出血症状5例,无1例出现并发症。结论长春地辛治疗难治性ITP疗效满意,不良反应小,花费低。 Objective To observe the therapeutic effect and safety of vindesine in the treatment of refractory immune thrombocytopenic purpura (ITP). Methods Eight patients with refractory ITP were treated with continuous intravenous infusion of vindesine once a week. The clinical bleeding and platelet count were recorded after treatment. The adverse reactions were observed. Results After treatment, the platelets increased to 100 × 109 / L with no symptoms of hemorrhage in 3 cases. After treatment, the platelets increased to 30 × 109 / L or at least 2 times more than the basal platelet count, 5 cases had no bleeding symptoms and none had complications . Conclusion Valsartan is effective in treating refractory ITP with small adverse reactions and low cost.