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目的 :研究不同浓度的月桂氮芯卓 酮对阿司匹林小鼠离体皮肤渗透性的影响。方法 :用改良的Franze扩散池 ,选不同浓度的月桂氮芯卓 酮 (0 %,2 %,5 %)作促渗剂 ,紫外法测定药物累积释放量 (Q)、稳态流量 (J)、渗透系数 (KP)。结果 :含 2 %和5 %月桂氮芯卓 酮的乳膏的稳态流量 (J)分别比空白乳膏增加 14.9%和 6 .6 %。结论 :含不同浓度的月桂氮芯卓 酮均可促进阿司匹林的透过 ,药物从乳剂型基质向皮肤的渗透符合Higuchi方程。
OBJECTIVE: To study the effects of different concentrations of Azithromycin on the in vitro skin permeability of aspirin mice. Methods: Cumulative drug release (Q) and steady state flow (J) were measured by ultraviolet spectrophotometry with a modified Franze diffusion cell with different concentrations of laurel nadol (0%, 2%, 5% , Permeability coefficient (KP). Results: The steady state flow (J) of creams containing 2% and 5% laurocapram were increased by 14.9% and 6.6%, respectively, compared to blank cream. CONCLUSION: Aspirin can be permeated with different concentrations of cinnamic acid. The osmotic of drug from emulsion matrix to skin conforms to Higuchi’s equation.