目的 :探讨鼻泪管黏膜相关淋巴组织的组织学特点 ,初步揭示泪道炎症不易治愈的局部原因。方法 :通过常规苏木精 伊红染色 ,利用图像分析仪对兔鼻泪管、鼻腔、咽腔和气管黏膜中的淋巴滤泡发育情况 ,高内皮静脉 (HEV)的分布情况及其周围淋巴细胞浸润的密度进行分析。结果 :鼻泪管黏膜组织中淋巴滤泡和HEV的数量及其周围淋巴细胞浸润的程度均低于鼻腔、咽腔和气管黏膜 (P <0 .0 1)。结论 :正常情况下鼻泪管黏膜的局部免疫反应程度低于鼻腔、咽腔和气管黏膜 ,其黏膜下淋巴组织欠发达可能是泪道炎症不易治愈的主要原因。 Objective: To investigate the histological characteristics of nasolacrimal duct mucosa-associated lymphoid tissue and to reveal the local causes of lacrimal duct inflammation that are not easily cured. Methods: The development of lymphatic follicles in rabbits nasolacrimal duct, nasal cavity, pharyngeal cavity and trachea mucosa were observed by conventional hematoxylin-eosin staining. The distribution of high endothelial vein (HEV) and its peripheral lymphocytes Infiltration density analysis. Results: The number of lymphoid follicles and HEV in mucosa of nasolacrimal duct and the infiltration of peripheral lymphocytes were lower than those in nasal, pharyngeal and tracheal mucosa (P <0.01). CONCLUSION: Local mucosal nasolacrimal duct mucosa under normal circumstances, the degree of local immune reaction is lower than the nasal cavity, pharynx and tracheal mucosa, the sub-lymphoid tissue may be less developed lacrimal duct inflammation is difficult to cure the main reason.