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高能质子是空间辐射的重要类型。本文用激光Raman光谱技术,研究了高能质子(27.9 MeV)对水溶液中DNA辐射作用的分子机理。通过解析其特征Raman谱线,获得DNA空间结构微观损伤的以下信息:(1)维系双螺旋结构的碱基间氢键部分断裂;(2)4种碱基均被损伤,其中腺嘌呤环的破坏最重;(3)脱氧核糖发生了明显的变化;(4)骨架磷酸离子(PO_2~-)和磷酸二酯(PO_2)的损伤严重,并出现单、双链的断裂;(5)B型构象的数量显著减少。
High-energy protons are an important type of radiation in space. In this paper, laser Raman spectroscopy was used to study the molecular mechanism of high-energy protons (27.9 MeV) on DNA radiation in aqueous solution. By analyzing its characteristic Raman spectra, the following information about microscopic damage of DNA spatial structure was obtained: (1) some hydrogen bonds breaking between bases in the double helix structure were broken; (2) all four kinds of bases were damaged, among which adenine ring (3) Deoxyribose changed obviously; (4) The damage of PO_2 ~ - and PO_2 was serious, and single and double strand breaks appeared; (5) B The number of conformations is significantly reduced.