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目的了解北京铁路局天津铁路疾病预防控制所辖区内人群戊型肝炎病毒IgM(HEV-IgM)抗体的水平和分布状况及丙氨酸转氨酶(ALT)和总胆红素(TBil)2项生化指标的基本情况,为今后预防工作提供科学依据。方法采用血清流行病学调查方法,对辖区内9 297名参加预防性健康检查的观察对象,利用酶联免疫吸附试验(ELISA),对其血清中HEV-IgM抗体进行检测,同时利用生化分析仪检测其ALT和TBil水平,并进行统计分析。结果 9 297名观察者中,HEV-IgM抗体阳性率为0.25%。HEV-IgM抗体阳性者平均ALT及TBil水平无显著增高。对1例HEV-IgM抗体阳性者进行跟踪检测,其HEV-IgM抗体在8个月内未见下降,其ALT及TBil水平也无显著增高。结论该辖区内HEV呈隐性潜伏感染,健康人群内有传播HEV病毒的风险。
Objective To understand the levels and distribution of HEV IgM antibodies and the biochemical indicators of alanine aminotransferase (ALT) and total bilirubin (TBil) in the area under the jurisdiction of Tianjin Railway Disease Prevention and Control of Beijing Railway Bureau. The basic situation for the prevention of future work to provide a scientific basis. Methods The serological epidemiological survey method was used to detect the 9 297 subjects participating in the preventive health examination in the area. The serum HEV-IgM antibody was detected by enzyme-linked immunosorbent assay (ELISA) The levels of ALT and TBil were detected and statistically analyzed. Results Among 9 297 observers, the positive rate of HEV-IgM antibody was 0.25%. There was no significant increase in mean ALT and TBil levels in HEV-IgM-positive patients. One case of HEV-IgM antibody-positive patients were followed up. The antibody against HEV-IgM did not decline within 8 months and the levels of ALT and TBil were also not significantly increased. Conclusion HEV is latent latent infection in this area, and there is a risk of transmitting HEV virus in healthy population.